Applications
The applications of chemical protein synthesis cover a wide range of laboratory processes:
- Non-natural amino acids:Introduction of non-natural residue into proteins
- Post-translation modification: Specific introduction of PTM: sulfonation, phosporylation, glycosilation, ubiquitination among the others
- Protein backbone modification: Modification of polypeptide backbone structure:
- Oxime
- Triazole
- Thioether
- Mirror image D-proteins: Synthesis of an entire protein with D-amino acids
- Specific labeling: Specific labeling at precise sites such as
- Fluorescent Dyes
- Biotin
- ligands (DOTA, DTPA)
- Functional group for bioorthogonal chemistry and click chemistry: cyclooctine, azide etc.
