Category: Scientific Publications en

VHH characterization. Comparison of recombinant with chemically synthesized anti‐HER2 VHH

Authors :  Lucie Hartmann, Thomas Botzanowski, Mathieu Galibert (GENEPEP), Magali Jullian (GENEPEP), Eric Chabrol, Gabrielle Zeder-Lutz, Valérie Kugler, Johann Stojko, Jean-Marc Strub, Gilles Ferry, Lukasz Frankiewicz (GENEPEP), Karine Puget (GENEPEP), Renaud Wagner, Sarah Cianférani, Jean A. Boutin

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Saïd Jebors, Project Leader at GENEPEP is the author of the publication “Self-mineralization and assembly of a bis-silylated Phe–Phe pseudodipeptide to a structured bioorganic–inorganic material ».

 This word has been produced by Saïd Jebors, Laurine Valot, Cécile Echalier, Baptiste Legrand,  Remi Mikhaleff,  Arie Van Der Lee,  Raul Arenal,  Pascal Dumy,  Muriel Amblard,  Jean Martinez,  Ahmad Mehdi  et Gilles Subra.

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Mathieu Galibert, Project Leader at GENEPEP is co-author of the publication “Imaging of extracellular cathepsin S activity by a selective near infrared fluorescence substrate-based probe ».

This word has been produced by Mylène Wartenberg, Ahlame Saidi, Mathieu Galibert, Alix Joulin-Giet, Julien Burlaud-Gaillard, Fabien Lecaille, Christopher J.Scott, Vincent Aucagne, Agnès F.Delmas, Gilles Lalmanach.

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GENEPEP and Prestwick Chemical now offer a new library of macrocyclic peptides. (more…)

GENEPEP in collaboration with SERVIER published new publication on Ubiquitine studies. During the project GENEPEP was responsible for the chemical synthesis of the Ubiquitine coupled to different peptidic substrates through side chain of the lysine.

M. Bacchi, B. Fould, M. Jullian, A. Kreiter, A. Maurras, O. Nosjean, T. Coursindel, K. Puget, G. Ferry and J. A. Boutin, Screening ubiquitin specific protease activities using chemically synthesized ubiquitin and ubiquitinated peptides, Anal Biochem, 2017, 519, 57-70.

GENEPEP in collaboration with SERVIER published latest results on Calstabin 2 studies. GENEPEP was responsible for the chemical synthesis of the protein by Native Chemical Ligation (NCL).

M. Bacchi, M. Jullian, S. Sirigu, B. Fould, T. Huet, L. Bruyand, M. Antoine, L. Vuillard, L. Ronga, L. M. Chavas, O. Nosjean, G. Ferry, K. Puget and J. A. Boutin, Total chemical synthesis, refolding, and crystallographic structure of fully active immunophilin calstabin 2 (FKBP12.6), Protein Sci, 2016, 25, 2225-2242.